"Nullification is the political movement of the 21st century"

In a very good essay in Chronicles (Jan 2017) Brion McClanahan says that "nullification is the political movement of the 21st century." We have to move back to the original federalism, localism, and decentralization of the Constitution. If 21 states can constitutional nullify national pot laws they can nullify other overly-centralized laws, and give real power back to the states.

My concern would be in staying strong enough as a large territorial nation to defend ourselves against other large nations or empires, but we can have federalism and a strong defense when needed. I would also eventually (and legally) want to take the federalism of states to its most natural conclusion, which is an ethnopluralism of ethnostates. Then real human nature, which remains ethnocentric and group-orientated, even more than individualistic, can truly "think locally and act locally," as Mclanahan puts it.